On the assumption that you've already cleaned the disk. Are there any scratches (or cracks) near the hub? When loading a disk, the operating system will try to load the directory, which is at the start of the disk. If it cannot recognize the format, it gives the "no disk" status.
I also assume that this isn't an UHD disk.
Not a MakeMKV issue
Re: Not a MakeMKV issue
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How to aid in finding the answer to your problem: Activating Debug Logging
How to aid in finding the answer to your problem: Activating Debug Logging